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It downregulates p53 and upregulates the expression of SLC7A11 and GPX4, suggesting that it improves cartilage degradation in osteoarthritis by inhibiting ferroptosis through the regulation of the p53 signaling pathway, indicating its potential therapeutic effect in osteoarthritis [166]

PEA is thought to work by supporting the inflammatory response through the PPAR-a receptor, COX-2 and through effects on NF-kappaB signaling while also by restoring balance in the endocannabinoid system

Oral precursors generally work because they are easily absorbed into cells and converted to NAD+

Moreover, even if certain elimination diets are not recommended, patients should undergo evaluation for potential deficiencies of micronutrients and vitamins, especially in cases when gastrointestinal autoimmune comorbidities feature (Shaheen et al

it's a fundamental requirement of good science